A Prelude
The first trailer for next year’s sequel film X-Men: Days of Future Past won’t be released until October 29 but today director Bryan Singer gives us a quick taste of what’s to come. Singer posted a short 6 second teaser preview of the full trailer due out next week. Click the embed above to watch the teaser for the trailer to get your first taste of X-Men: Days of Future Past.
In recent years, we've watched with wonder as boring old yellow halogen car headlights have been replaced with futuristic, Tron-like LEDs. Now, that transition is about to take place on the city scale, as New York City prepares to replace its street lamps—all 250,000 of them—with LEDs.
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Source: http://feeds.gawker.com/~r/gizmodo/full/~3/IytfmXISkIY/nyc-is-replacing-its-250-000-street-lights-with-leds-1451637125
You may not have been bitten by a radioactive spider, but thanks to Marvel's new Creativity Studio and its accompanying stylus, you can at least draw the person who did. The app and pen combo, which is the fruit of a collaboration between Marvel and eKids, is a tool for those young imaginations out ...
Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/8IQnhyyQGUM/A post at Space.com led us to a NASA video that we find fascinating.
In it, astronaut Karen Nyberg, one of the six people now aboard the International Space Station, demonstrates how little effort it takes to move around in microgravity.
She takes a single strand of hair from her head, stretches it across a handrail and pushes off. You can watch as Nyberg then floats across the station. (And, yes, there's a connection to Sandra Bullock and the movie Gravity, as you'll see.)
This isn't her first hair-related video. In July, Nyberg demonstrated how she washes those long locks.
The 44-year-old Nyberg, who has a doctorate in mechanical engineering from the University of Texas, flew on a Space Shuttle Discovery mission to the space station in 2008. Her second trip to space began on May 28. She's scheduled to return to Earth on Nov. 10.
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PUBLIC RELEASE DATE: 24-Oct-2013
ShareContact: David Bricker
dmbricker@houstonmethodist.org
832-667-5811
Houston Methodist
HOUSTON -- ( Oct. 24, 2013 ) -- Just 13 days in space may be enough to cause profound changes in eye structure and gene expression, report researchers from Houston Methodist, NASA Johnson Space Center, and two other institutions in the October 2013 issue of Gravitational and Space Research.
The study, which looked at how low gravity and radiation and oxidative damage impacts mice, is the first to examine eye-related gene expression and cell behavior after spaceflight.
"We found many changes in the expression of genes that help cells cope with oxidative stress in the retina, possibly caused by radiation exposure," said Houston Methodist pathologist Patricia Chvez-Barrios, M.D., the study's principal investigator. "These changes were partially reversible upon return to Earth. We also saw optic nerve changes consistent with mechanical injury, but these changes did not resolve. And we saw changes in the expression of DNA damage repair genes and in apoptotic pathways, which help the body destroy cells that are irreparably damaged."
Since 2001, studies have shown astronauts are at increased risk of developing eye problems, like premature age-related macular degeneration. Experts suspect the cause is low gravity, heightened exposure to solar radiation, or a combination of the two.
In Nov. 2011, a NASA-sponsored Ophthalmology study of seven astronauts showed that all seven had experienced eye problems after spending at least six months in space. Doctors saw a flattening of the back of the eyeball, folding of the choroid (vascular tissue behind the retina), excess fluid around and presumed swelling of the optic nerve, or some combination of these.
High-energy radiation from the Sun can cause nasty, extremely damaging chemical reactions in cells, collectively called oxidative stress. Earth's atmosphere reflects or absorbs much of this radiation and is, ironically, a much better shield than the thick metal hulls of space shuttles and the International Space Station.
Damage to eyes isn't merely a long-term health issue for some astronauts back on Earth -- it could interfere with future missions in which any loss of focus or vision makes it difficult for humans to complete long missions, such as round-trip travel to Mars (12 to 16 months) or to the moons of Jupiter (about two years). If both radiation exposure and gravity loss are to blame, one solution to save astronauts' eyes might be a spacecraft with a more protective hull and inside, a spinning hamster wheel that simulates gravity similar to those envisioned by futurist author Arthur C. Clarke and realized in Stanley Kubrick's film, 2001: A Space Odyssey.
To determine the impact of radiation exposure on eyes, Chvez-Barrios and lead author Susana Zanello, Ph.D., a space life scientist at NASA Johnson Space Center, examined mouse retinal gene expression on the 1st, 5th, and 7th days following a 13-day trip aboard space shuttle Discovery (STS-133), measuring indicators of oxidative and cellular stress. The researchers also examined the eyes and surrounding tissues for broad changes in structure and shape that could relate to low gravity. They maintained two controls on Earth -- one in which mice were kept in the same general conditions as those aboard the shuttle, and one in which mice were maintained in typical, Earth-based care facilities.
Mice returning to Earth showed immediate evidence of oxidative stress in their retinas. But the increased expression of six oxidative stress response genes appeared to return to normal by the seventh day on Earth. An indicator of oxidative stress in the cornea was also elevated one day after mice had returned from orbit, but returned to near-normal levels by the seventh day.
"This suggests oxidative stress in the retina and lens are at least partially reversible under the circumstances of the experiment," Chvez-Barrios said. "This was after a relatively short time in orbit. We don't know if damage caused by longer periods of oxidative stress will be more severe. Only more studies with longer exposure times may help answer this question."
In the mice that had been to orbit, the researchers also found an increase in beta-amyloid in their optic nerves, and this increase persisted after seven days on Earth. Beta-amyloid is associated with traumatic brain injury in humans, and was not detected in the mice that remained on Earth. The researchers also found an increased number of glial cells -- cells that respond to injury -- in the optic nerves of mice that had been to space. It is not known whether the deposit of beta-amyloid and increased glial cells were caused by sustained low gravity or during the trips to or from Earth orbit. The researchers also found orbiting mice were expressing elevated levels of caspase-3 in the retinal pigment epithelium. Caspaces are enzyme precursors that help the immune system destroy damaged cells in a process called apoptosis. Abnormalities of the epithelium are associated with development of age-related macular degeneration.
Chvez-Barrios and colleagues found changes in cell and tissue shape and fluid balance similar to what has been reported from previous studies, specifically studies of astronauts who had experienced optic nerve changes.
The study described in the Gravitational and Space Research paper was small -- 18 mice in nine different condition groups. Space is limited aboard orbital missions.
"We say in the paper these results should be thought of as preliminary, like a pilot study," Chvez-Barrios said. "We think our results are plausible based on what we know from previous studies of structural changes and damage caused by oxidative stress and changes in the eyes of astronauts returning to Earth, but additional experiments are needed to confirm what we are reporting about gene expression, cellular behavior and mechanisms of damage."
Chvez-Barrios also said the strain of mice used in the study are known to be unusually sensitive to light, and that the severity of oxidative, cellular, and tissue problems her group saw would probably be milder in healthy human eyes.
###
Chvez-Barrios is the director of Houston Methodist's Ocular Pathology Research Laboratory and is a Weill Cornell Medical College professor of ophthalmology and of pathology and laboratory medicine. Zanello is affiliated with the Universities Space Research Association, a consortium founded by NASA and the National Academy of Sciences. Also contributing to the Gravitational and Space Research paper were Corey Theriot, Ph.D. (University of Texas Medical Branch at Galveston) and Claudia Prospero Ponce, M.D. (University of Arizona Health Sciences Center). Work was funded by the NASA Human Research Program.
To speak with Dr. Chvez-Barrios, please contact David Bricker, Houston Methodist, at 832-667-5811 or dmbricker@houstonmethodist.org.
Share
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
PUBLIC RELEASE DATE: 24-Oct-2013
ShareContact: David Bricker
dmbricker@houstonmethodist.org
832-667-5811
Houston Methodist
HOUSTON -- ( Oct. 24, 2013 ) -- Just 13 days in space may be enough to cause profound changes in eye structure and gene expression, report researchers from Houston Methodist, NASA Johnson Space Center, and two other institutions in the October 2013 issue of Gravitational and Space Research.
The study, which looked at how low gravity and radiation and oxidative damage impacts mice, is the first to examine eye-related gene expression and cell behavior after spaceflight.
"We found many changes in the expression of genes that help cells cope with oxidative stress in the retina, possibly caused by radiation exposure," said Houston Methodist pathologist Patricia Chvez-Barrios, M.D., the study's principal investigator. "These changes were partially reversible upon return to Earth. We also saw optic nerve changes consistent with mechanical injury, but these changes did not resolve. And we saw changes in the expression of DNA damage repair genes and in apoptotic pathways, which help the body destroy cells that are irreparably damaged."
Since 2001, studies have shown astronauts are at increased risk of developing eye problems, like premature age-related macular degeneration. Experts suspect the cause is low gravity, heightened exposure to solar radiation, or a combination of the two.
In Nov. 2011, a NASA-sponsored Ophthalmology study of seven astronauts showed that all seven had experienced eye problems after spending at least six months in space. Doctors saw a flattening of the back of the eyeball, folding of the choroid (vascular tissue behind the retina), excess fluid around and presumed swelling of the optic nerve, or some combination of these.
High-energy radiation from the Sun can cause nasty, extremely damaging chemical reactions in cells, collectively called oxidative stress. Earth's atmosphere reflects or absorbs much of this radiation and is, ironically, a much better shield than the thick metal hulls of space shuttles and the International Space Station.
Damage to eyes isn't merely a long-term health issue for some astronauts back on Earth -- it could interfere with future missions in which any loss of focus or vision makes it difficult for humans to complete long missions, such as round-trip travel to Mars (12 to 16 months) or to the moons of Jupiter (about two years). If both radiation exposure and gravity loss are to blame, one solution to save astronauts' eyes might be a spacecraft with a more protective hull and inside, a spinning hamster wheel that simulates gravity similar to those envisioned by futurist author Arthur C. Clarke and realized in Stanley Kubrick's film, 2001: A Space Odyssey.
To determine the impact of radiation exposure on eyes, Chvez-Barrios and lead author Susana Zanello, Ph.D., a space life scientist at NASA Johnson Space Center, examined mouse retinal gene expression on the 1st, 5th, and 7th days following a 13-day trip aboard space shuttle Discovery (STS-133), measuring indicators of oxidative and cellular stress. The researchers also examined the eyes and surrounding tissues for broad changes in structure and shape that could relate to low gravity. They maintained two controls on Earth -- one in which mice were kept in the same general conditions as those aboard the shuttle, and one in which mice were maintained in typical, Earth-based care facilities.
Mice returning to Earth showed immediate evidence of oxidative stress in their retinas. But the increased expression of six oxidative stress response genes appeared to return to normal by the seventh day on Earth. An indicator of oxidative stress in the cornea was also elevated one day after mice had returned from orbit, but returned to near-normal levels by the seventh day.
"This suggests oxidative stress in the retina and lens are at least partially reversible under the circumstances of the experiment," Chvez-Barrios said. "This was after a relatively short time in orbit. We don't know if damage caused by longer periods of oxidative stress will be more severe. Only more studies with longer exposure times may help answer this question."
In the mice that had been to orbit, the researchers also found an increase in beta-amyloid in their optic nerves, and this increase persisted after seven days on Earth. Beta-amyloid is associated with traumatic brain injury in humans, and was not detected in the mice that remained on Earth. The researchers also found an increased number of glial cells -- cells that respond to injury -- in the optic nerves of mice that had been to space. It is not known whether the deposit of beta-amyloid and increased glial cells were caused by sustained low gravity or during the trips to or from Earth orbit. The researchers also found orbiting mice were expressing elevated levels of caspase-3 in the retinal pigment epithelium. Caspaces are enzyme precursors that help the immune system destroy damaged cells in a process called apoptosis. Abnormalities of the epithelium are associated with development of age-related macular degeneration.
Chvez-Barrios and colleagues found changes in cell and tissue shape and fluid balance similar to what has been reported from previous studies, specifically studies of astronauts who had experienced optic nerve changes.
The study described in the Gravitational and Space Research paper was small -- 18 mice in nine different condition groups. Space is limited aboard orbital missions.
"We say in the paper these results should be thought of as preliminary, like a pilot study," Chvez-Barrios said. "We think our results are plausible based on what we know from previous studies of structural changes and damage caused by oxidative stress and changes in the eyes of astronauts returning to Earth, but additional experiments are needed to confirm what we are reporting about gene expression, cellular behavior and mechanisms of damage."
Chvez-Barrios also said the strain of mice used in the study are known to be unusually sensitive to light, and that the severity of oxidative, cellular, and tissue problems her group saw would probably be milder in healthy human eyes.
###
Chvez-Barrios is the director of Houston Methodist's Ocular Pathology Research Laboratory and is a Weill Cornell Medical College professor of ophthalmology and of pathology and laboratory medicine. Zanello is affiliated with the Universities Space Research Association, a consortium founded by NASA and the National Academy of Sciences. Also contributing to the Gravitational and Space Research paper were Corey Theriot, Ph.D. (University of Texas Medical Branch at Galveston) and Claudia Prospero Ponce, M.D. (University of Arizona Health Sciences Center). Work was funded by the NASA Human Research Program.
To speak with Dr. Chvez-Barrios, please contact David Bricker, Houston Methodist, at 832-667-5811 or dmbricker@houstonmethodist.org.
Share
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Ben Rothstein/Twentieth Century Fox
"The Wolverine"
The Wolverine 2 clawed its way to the top of the Chinese box office charts this week, taking $18.17 million (111.2 million yuan) in its first week despite bowing weeks after it originally premiered in Hong Kong and other overseas markets.
The China haul helped to push Twentieth Century Fox International's global ticket sales for 2013 past the $2 billion mark.
PHOTOS: Hugh Jackman: An Unconventional Superstar
The movie opened in July in most other markets. Normally, a late release in China means viewers will have already accessed the film via pirate DVDs and illegal downloads, hurting ticket sales.
However, the movie's spectacular action scenes and strong performance by Hugh Jackman seem to have successfully lured the local fanboy audiences into China's cinemas. Jackman came to China for the premiere, and made a big splash in local press.
There were 2.96 million admissions for the film in the first week.
PHOTOS: Inside Hollywood's Surprise Trip to 'China's Oscars'
According to data from Beijing-based Entgroup, for the week of Oct. 14-20, Wolverine beat out Donnie Yen's Shenzhen-set cop movie Special ID, which took $10.9 million (66.52 million yuan), while Louis Leterrier's Now You See Me continued its respectable if unspectacular run, taking in another $7.95 million to bring its total to $17.91 million.
Love Will Tear Us Apart appeared to pick up pace during the week, taking in $6.36 million. The movie features martial arts specialist Feng Shaofeng and Ni Ni, best known internationally for her role in Zhang Yimou's Flowers of War.
Meanwhile, Tsui Hark's Young Detective Dee: Rise of the Sea Dragon continued to edge closer to the $100 million box office mark. The fantasy prequel took $5.92 million during the week, bringing its cumulative total in the first 23 days on release to $94.7 million.
Dolly Parton has no trouble keeping up with the times. The 67-year-old country legend appears today on Queen Latifah's talk show, where she'll be seen doing an original rap -- yes, a rap -- that name-checks her goddaughter Miley Cyrus. Check it out:
Source: http://www.ivillage.com/watch-dolly-parton-raps-about-miley-cyrus-queen-latifahs-talk-show/1-a-550199?dst=iv%3AiVillage%3Awatch-dolly-parton-raps-about-miley-cyrus-queen-latifahs-talk-show-550199
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