Heart muscle cell grafts suppress arrhythmias after heart attacks in animal study

ScienceDaily (Aug. 5, 2012) ? Researchers have made a major advance in efforts to regenerate damaged hearts. Grafts of human cardiac muscle cells, grown from embryonic stem cells, coupled electrically and contracted synchronously with host muscle following transplantation in guinea pig hearts.

The grafts also reduced the incidence of arrhythmias (irregular heart rhythms) in a guinea pig model of myocardial infarction (commonly known as a heart attack).

This finding from University of Washington-led research is reported in the Aug. 5 issue of Nature.

The paper's senior author, Dr. Michael Laflamme, said, "These results provide strong evidence that human cardiac muscle cell grafts meet physiological criteria for true heart regeneration. This supports the continued development of human embryonic stem cell-based heart therapies for both mechanical and electrical repair of the heart."

During a myocardial infarction the flow of oxygen-rich blood to the heart muscle is interrupted by formation of a clot, causing death of the down-stream heart muscle and its eventual replacement by scar tissue. This can cause mechanical problems with filling and emptying the heart, and it can also interfere with the electrical signals that pace the heartbeat.

In this study, the guinea pigs' hearts had an injury to the left ventricle, the thick walled lower chamber in the heart that pumps oxygenated blood to the body. The injury left a scar and thinned the ventricle, which showed both reduced pump function and greater susceptibility to arrhythmias.

Injured hearts that received the human cardiac muscle cell grafts showed partial re-muscularization of the scarred left ventricle.

Consistent with previous studies, tests showed that the injured hearts with the human cardiac cell grafts had improved mechanical function.

More surprisingly, these hearts showed fewer arrhythmias than did injured hearts without such grafts.

"We showed a couple years ago that transplanting human embryonic stem cell-derived heart muscle cells improves the pumping activity of injured hearts," said Dr. Michael Laflamme, UW associate professor of pathology and a member of the UW Center for Cardiovascular Biology and the Institute for Stem Cell & Regenerative Medicine.

"In this recent paper," he explained, "we show that the transplantation of these cells also reduces the incidence of arrhythmias [heart rhythm disturbances]."

Laflamme and Dr. Charles E. Murry, UW professor of pathology, bioengineering and medicine, Division of Cardiology, were the senior authors of the paper. The lead authors were Drs. Yuji Shiba and Sarah Fernandes in the UW Department of Pathology. Shiba is also from the Department of Cardiovascular Medicine at Shinshu University in Japan.

Because arrhythmias are a major cause of death in patients after a heart attack, Laflamme pointed out, this effect might be clinically useful if proven successful in large animal models as well.

Scientists had been worried that transplanting heart muscle cells derived from embryonic stem cells would promote arrhythmias.

"Instead, they suppress arrhythmias, at least in the guinea pig model," Laflamme and his team were pleased to discover.

While Laflamme and Murry had previously shown that transplanting these types of cell grafts improved pump function in injured hearts, Laflamme noted that it had not been previously determined if the grafts actually coupled and fired synchronously with heart's original muscle.

There was the possibility, he suggested, that they exerted their beneficial effects indirectly, perhaps by releasing signaling molecules, rather than by forming new force-generating units.

"In our study, we discovered that the heart cell grafts do, in fact, couple to the guinea pig hearts," he said.

The research team found the heart cell grafts electrically coupled in all of the normal, uninjured hearts into which they were transplanted, and in the majority of the injured hearts.

The researchers were able to observe this coupling by transplanting human heart muscle cells that were genetically modified to flash every time they fired. By correlating this optical signal from the graft cells with the electrocardiogram -- electrical signals from the recipient heart -- the researchers were able to determine whether cell grafts were electrically coupled with the animal's heart.

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The above story is reprinted from materials provided by University of Washington, via EurekAlert!, a service of AAAS.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/gOkvJ-Pj8bY/120805144845.htm

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Could tougher voting laws squelch the youth vote?

CHICAGO (AP) ? Gone are the days when young voters weren't taken seriously. In 2008, they helped propel Barack Obama into the Oval Office, supporting him by a 2-1 margin.

But that higher profile also has landed them in the middle of the debate over some state laws that regulate voter registration and how people identify themselves at the polls.

Since the last election, Pennsylvania, Kansas, Wisconsin and Texas and other states have tried to limit or ban the use of student IDs as voter identification. In Florida, lawmakers tried to limit "third party" organizations, including student groups, from registering new voters.

Proponents of voter ID and registration laws say the laws are intended to combat voter fraud. The intent, they say, is to make sure people who are voting are who they say they are and have the right to vote.

"In this day and age, nothing could be more rational than requiring a photo ID when voters come to the polls," Pennsylvania's senior deputy attorney general, Patrick Cawley, said recently when defending the state's new law in court.

Others see these efforts as attempts to squelch the aspirations of the budding young voting bloc and other groups, and they're using that claim to try to get more young people fired up.

"You think your vote doesn't matter? Then why are they trying so hard to take it away from you?" asks Heather Smith, president of Rock the Vote, a group that works to register young voters. "It does demonstrate the power they have."

Smith notes that it's not just an issue for college students.

She was teaching a civics class for graduating seniors at an inner-city high school in Philadelphia this spring and asked how many among them had driver's licenses that could be used, if the Pennsylvania law requiring a photo ID to vote were to survive the legal challenge.

"They looked at me like I had two heads," she says. Only two students in the room of 200 raised a hand; few of the students had cars.

These are the sort of stories that have led some students to get involved, particularly on college campuses.

In Florida, Rock The Vote joined with the League of Women Voters to challenge restrictions on "third party" voter registration. A federal judge said last spring that many of the restrictions made it too difficult for legitimate voter registration organizations to do their work. During the fight, students at the University of Central Florida placed ironing boards around campus, a symbol that they were "pressing the issue."

Now, while most college campuses are relatively quiet, some of those students have taken it upon themselves to register their peers during freshman orientation this summer.

"We feel like it's up to us," says Anna Eskamani, a 22-year-old graduate student and a leader at the Florida school.

In Pennsylvania, when lawmakers were proposing the voter ID law there, 22-year-old Adam Boyer was among students who asked them to reconsider an outright ban on the use of student IDs.

"I'd like to think that the proponents of this law weren't trying to disenfranchise certain demographics. I hope it was an oversight on their part, and I think that was the case," says Boyer, a recent graduate of Penn State who plans to attend law school at Villanova this fall.

Pennsylvania lawmakers decided to allow "valid" student IDs, meaning they had to have expiration dates. But most colleges and universities in Pennsylvania didn't have such dates on their IDs.

So students and other groups that advocate for them have been working with universities in Pennsylvania and states such as Wisconsin to add them. A state judge struck down Wisconsin's voter ID law; that ruling is being appealed.

New IDs at institutions such as Penn State, for instance, now have expiration dates. Returning students also can get an expiration sticker to put on their IDs, a common plan at schools that are addressing the ID issue.

Joel Weidner, a Penn State official who helps oversee ID policy, says the school is most concerned about out-of-state students who might rely on a student ID to vote if they don't have a Pennsylvania driver's license. Of the 80,000 Penn State students on campuses statewide, he estimates that about 10,000 are from other states.

But in many instances, returning students still have to be aware that they need the expiration sticker and know where to get one.

"What we don't want to see is a school offering up a change to students but doing it quietly," says Dan Vicuna, staff attorney and campus vote project coordinator at the Fair Elections Legal Network in Washington. "We really hope it will be coupled with a real public awareness campaign."

Voter ID and registration aren't the only voting issues on campuses.

Long lines and a lack of polling places have been problems for students in past elections, particularly in 2008. So some universities are trying to get polling places on campus. Arizona State is among those that recently approached election officials and got one.

In Ohio, student groups are working with county officials to lengthen early voting

"Some have been more receptive to that than others," says Will Klatt, a recent graduate of Ohio University who is now a senior organizer for the Ohio Student Association.

All the rules, and the differences in them state to state and even county to county, can create a lot of confusion for young voters, some of whom are voting for the first time

In Wisconsin, during a gubernatorial recall election in June, the League of Women Voters received 200 calls from students who said voting requirements caused confusion at the polls. Many, the league said, left without voting. The confusion, in that instance, was over a requirement that Wisconsin voters live in a precinct for 28 days to be eligible to vote there. That's a tricky requirement for students, who are often mobile in the summer months.

Last year in Maine, groups such as the American Civil Liberties Union criticized Secretary of State Charlie Summers after he sent letters to out-of state students at four universities telling them they needed to register their vehicles in Maine and get driver's licenses there if they wanted to continue voting in the state. Some saw the move as voter intimidation and a violation of the Voting Rights Act, particularly because Summers found no evidence of voter fraud in an investigation that prompted the letters.

Summers' spokeswoman said the secretary of state had consulted with the Maine attorney general and "acted in accordance with all state and federal laws."

The U.S. Supreme Court has sided with students on this issue and their ability to vote where they attend school, even when they've come from another state.

"So students should be registering in the communities that they feel are home ? whether that's their parents' home or their apartment or their dorm room," says Lee Rowland, counsel for the Democracy Program at the Brennan Center for Justice, a nonpartisan legal think tank in New York. "It is a constitutional right to vote."

To help them understand that right, she says the Brennan Center created an online guide for students with pages that detail voting rules and requirements in each state ? http://bit.ly/Pl1pbE

It's not uncommon for out-of-state students to vote where they think their vote has the most impact. So if they attend a school in a swing state, they often vote there. It also can simply just be a matter of convenience, and a way to avoid going through the process of getting an absentee ballot.

Right now, Tennessee, Pennsylvania, Kansas, Indiana and Georgia are among states with voter ID requirements in place. Tennessee is the only state that bans use of any student ID. Others limit use to state institutions and/or require proof that the ID is valid, such as the expiration date.

Wisconsin, Texas, South Carolina and Virginia are among states where voter ID laws are on hold due to legal challenges.

But will young people vote in November in the same numbers as they did in 2008?

Eskamani, the grad student in Florida, has noticed a lot of disillusionment among her peers over the economy and a political process they consider "anti-student."

"They feel beaten down," says Eskamani. "Instead of more passionate, I think sometimes they feel more frustrated."

Some think that frustration could fuel more involvement, especially as students return to campus this fall.

"My hope is that (voter ID and other laws) backfire and that young people find out and are annoyed by it ? and that it motivates them more to get out and vote," says Tobin Van Ostern, policy manager for Campus Progress, a Washington-based group that works on voting rights and other issues relevant to students.

If that happens, Eskamani tells her peers, "WE will determine who the next president of the United States is."

___

Martha Irvine is a national writer for The Associated Press. She can be reached at mirvine(at)ap.org or at http://twitter.com/irvineap

___

Online:

Voter registration laws: http://tinyurl.com/84d7jlz

Source: http://news.yahoo.com/could-tougher-voting-laws-squelch-youth-vote-132509578.html

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Video: Man?s angry reaction to marijuana arrest

>>> you know the type of person who doesn't anger easily but when they do it's epic? well, there's a guy like that in derby, vermont. the allegation here is he was angry about being arrested for marijuana possession and resisting arrest, so he got in his tractor and did the only thing he could do -- he crushed all eight police vehicles in the parking lot in town. he got them all. he crushed them so thoroughly there is not a working radio or radar detector. to get the rifles out of the trunks of the squad cars they had to use the jaws of life. he went about his work methodically and when done disappeared on route 5. things can get a little crazy up near the canadian border . tonight his tractor is parked because he is in custody.

Source: http://video.msnbc.msn.com/nightly-news/48496168/

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Total, I feel you will like both a particular and equally are excellent pre-workout supplements. After i have got a supply for the Vigor and Endurance method I take advantage of that and after i require a speedy take care of the Vega system does the trick. It provides me the electrical power while not the crash. You?ll find it, does not appear to be to elevate my coronary heart level just how other particular energy beverages are likely to perform. For more information to the Vega electricity ingest visit their web-site.

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Source: http://articlepdq.com/health-fitness/p90x-pre-workout-choix-vega-pre-training-session-strength/

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Malaysia SEO Companies Help Achieve Dealings Goals in the ...

The ubiquity of the internet and the current developments in modern technology make it possible for business enterprises and business owners to promote and market their products and services online. In their attempt to reach out to a wide array of clients and customers both locally and globally, corporations, business establishments, and individual entrepreneurs take the business competition to a higher level through the use of Search Engine Optimization or SEO services. Malaysia, as one of the biggest and fast-developing economies in Southeast Asia, constantly tries to cope with the demands and challenges of the commercial world. Big companies as well as small-scale and medium-scale enterprises in Malaysia have to compete with international companies to ensure their survival in the business world. One of the best ways to maintain a healthy competition between local Malaysian businesses and international enterprises is through the use of SEO services. By increasing their presence on the web through Malaysia SEO companies, Malaysian business enterprises and entrepreneurs can maintain their spot in the highly competitive and globalized industrial realm. They can also give to the rapid growth and development of the economy of the country. a href=?http://www.pixalwebdesign.com/seo-service.php?Malaysia SEO companies/a play a crucial role in ensuring that the goals of business enterprises and entrepreneurs are achieved through the use of the internet and other technological means.

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The author is a senior developer in SEO company and works with Pixal Network to assist and focus on design website and online software development. Pixal Network as a leading web design company can help anyone for web design, online marketing as well as search engine optimization at best possible.

Source: http://answers.apostoliccm.com/2012/08/malaysia-seo-companies-help-achieve-dealings-goals-in-the-country/

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Auto-tune your Direct Messages. A {growtoon}. - Schaefer Marketing ...

You?re in marketing for one reason: Grow. Grow your company, reputation, customers, impact, profits. Grow yourself. This is a community that will help. It will stretch your mind, connect you to fascinating people, and provide some fun along the way. I am so glad you?re here. -Mark Schaefer

Source: http://www.businessesgrow.com/2012/08/03/auto-tune-your-direct-messages-a-growtoon/

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WCPE Cinema Classics Weekend Celebration

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August 02, 2012 ?

Wake Forest, N.C. (PRWEB) Aug 02, 2012

During WCPE Cinema Classics Weekend, theClassicalStation.org celebrates sounds of a china screen

(August 2, 2012) WCPE Music Director William Woltz announces a weekend-long spectacular celebrating Great Classical Music in a cinema, Aug 11 and 12, 2012. Throughout this two-day festival, WCPE will share song from films trimming from undying to obscure. Theres newer song created for a movie, and aged masterpieces that make a movie. On Saturday we might ask your favorite cinema exemplary here.

Cinema Classics Weekend has turn one of WCPEs many renouned thesis programs, in partial since cinema call adult such low feelingsand not a tiny nostalgia, says Woltz, who is also a horde of Allegro. The soundtracks from cinema have changed us to tears, laughter, and substantially each tension in between.

For a wander down memory lane, hear such important exemplary works as:
Saturday 8/11
8:00 a.m. Haydn: Symphony no. 104 in D (London)
10:00 a.m. Bernstein, E.: Theme from The Magnificent Seven
12:00 p.m. Beethoven: Piano Sonata no. 14 in C-sharp Minor (Moonlight)
1:00 p.m. Gershwin: Rhapsody in Blue
3:00 p.m. Rossini: Overture to William Tell
4:00 p.m. Brahms: Symphony no. 1 in C Minor
5:00 p.m. Williams: Suite from Far and Away

Sunday8/12
7:00 a.m. Faur?: In Paradisum from Requiem
11:00 a.m. Mozart: Symphony no. 25 in G Minor
1:00 p.m. Addinsell: Warsaw Concerto
2:00 p.m. Respighi: The Pines of Rome
3:00 p.m. Shore: The Fellowship from The Fellowship of a Ring
4:00 p.m. Beethoven: Symphony no. 6 in F (Pastoral)
5:00 p.m. Rota: La Passarella di Addio

WCPEs 24/7 live promote of Great Classical Music, 24 Hours A Day can be accessed around a creation in several ways; on-line streaming in mixed formats, including IPv6, tiny plate home satellite reception, internal wire radio systems and normal radio broadcasting. A finish list of a ways WCPE is accessible with instructions for wire and satellite accepting can be found at: http://theclassicalstation.org/listen.shtml.

About WCPE:
With a 33 and year history, WCPE 89.7 FM is a non-commercial, 100 percent listener-supported, eccentric hire dedicated to value in Great Classical Music broadcasting. WCPE is listened worldwide on a Internet in mixed formats, including a subsequent era IPv6. Because WCPE receives no tax-derived support, a hire conducts dual on-air fundraising campaigns and dual vital mail-out campaigns per year to lift indispensable handling funds. For some-more information, revisit http://www.TheClassicalStation.org or call 919-556-5178.

Media Contact:
Curtis Brothers
919.556.5178
curtis(at)TheClassicalStation(dot)org

Read a full story during http://www.prweb.com/releases/2012/8/prweb9762024.htm.

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Source: http://hardmovie.net/wcpe-cinema-classics-weekend-celebration/

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