Amazon CEO Jeff Bezos says that his deep-sea sonar expedition in the Atlantic has located the five engines used to launch Neil Armstrong, Buzz Aldrin, and Michael Collins to the moon in 1969, and he plans to bring at least one of them to the surface.?
When NASA's mighty Saturn V rocket launched the historic Apollo 11 mission to land the first men on the moon in 1969, the five powerful engines that powered the booster's first stage dropped into the Atlantic Ocean and were lost forever.
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Lost, that is, until now.
A private expedition financed by Amazon.com founder and billionaire Jeff Bezos has discovered the five?F-1 rocket engines?used to launch Apollo 11 into space on July 16, 1969 and is drawing up plans to retrieve one or more so they can be publicly displayed.
"I'm excited to report that, using state-of-the-art deep sea sonar, the team has found the Apollo 11 engines lying 14,000 feet below the surface, and we're making plans to attempt to raise one or more of them from the ocean floor," Bezos wrote in a statement posted to the?Bezos Expeditions website. "We don't know yet what condition these engines might be in - they hit the ocean at high velocity and have been in salt water for more than 40 years. On the other hand, they're made of tough stuff, so we'll see."
NASA's Saturn V remains today, more than 40 years later, the largest and most powerful rocket ever built. It used a cluster of five 12.2-foot (3.7-meter) wide F-1 engines as its foundation, with each 18.5-foot (5.6-meter) tall engine capable of generating 1.5 million pounds of thrust ? about 32 million horsepower ? as it burned about 6,000 pounds of rocket fuel every second. [The World's Tallest Rockets Compared]
Bezos said he was only 5 years old when he watched with rapt attention when Apollo 11 astronauts Neil Armstrong, Buzz Aldrin and Michael Collins made their historic voyage to the moon. But it was only recently that a question struck his mind.
"A year or so ago, I started to wonder, with the right team of undersea pros, could we find and potentially recover the F-1 engines that started mankind's mission to the moon?" Bezos wrote.
It was then that Bezos began planning what his website billed as the F-1 Engine Recovery expedition.
If one of the Apollo 11 F-1 engines is ultimately recovered, it will be turned over to NASA, Bezos added.
"Though they've been on the ocean floor for a long time, the engines remain the property of NASA. If we are able to recover one of these F-1 engines that started mankind on its first journey to another heavenly body, I imagine that NASA would decide to make it available to the Smithsonian for all to see.," Bezos wrote. "If we're able to raise more than one engine, I've asked NASA if they would consider making it available to the excellent?Museum of Flight here in Seattle."
Fresh soup brand New Covent Garden is celebrating the ?Best of?British? with its latest soup of the month.
April?s soup of the month, ?Rosie?s Vintage Cheddar & Piccalilli soup? has?been created by amateur cook and consumer Rosie Garrish.
Rosie?s soup was chosen as a winner through New Covent Garden?s social?media campaign, which invites soup fans to submit their own recipes based?on a specific theme.
The theme set for April was ?Best of British? which welcomed recipes that?took inspiration from all things British, from home-grown ingredients and?modern twists on traditional dishes to exotic flavours that are now our nation?s?favourite dishes.
Nigel Parrott, New Covent Garden?s Group Marketing Director, said:
?Rosie?s Vintage Cheddar & Piccalilli Soup truly captures the Best of British?and is exactly the recipe we hoped to find when we set April?s theme.
New Covent Garden is celebrating the ?Best of British?
?April?s Soup of the Month truly kicks off Britain?s year of festivities.
?The?Union Jack packaging will attract consumers to the fixture who want to?embrace all that is British and are seeking unique but traditional flavours.?
Consumers are still encouraged by an on-pack call to action to submit their?recipes for future Soup of the Months at www.newcoventgardensoup.com,?where recipes, tips and blogs are encouraging further engagement with the?brand.
Rosie?s Vintage Cheddar & Piccalilli Soup will be available until the end of?April 2012 with an RRP of ?2.20 in outers of six.
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Creative Assembly's Mike Simpson says the popular Total War series of strategy games wouldn't work on the current console generation, just in terms of hardware requirements. "They don't have enough memory, by a large factor," Simpson tells Eurogamer. The audience for console games tends to be a little more action-oriented and a little less strategy focused, and the experiences are very different as well, he asserts. But there's hope yet, "for all sorts of reasons."
The user interface is another issue, according to Simpson, but it's fixable through solid game design. While he doesn't mention the Total War version coming to iOS, that's definitely a clear indicator that the game can work on platforms other than PC. And Simpson says that despite the differences, Creative Assembly has some "very clever ideas" on adapting its popular strategy games for the next wave of consoles and the pick-up-and-play style that go along with them.
It's always a good idea to have some hidden vegetable recipes up your sleeve. ?This is a simple pasta bake recipe with not only hidden vegetables but also hidden meat. ?Some kids get very picky when they are toddlers about eating fruits and vegetables and some even get picky with their protein. ?I posted about this a while back.
This is completely adaptable, change it as you see fit. ?You could use bacon or chorizo instead of some of the chicken, however, this will increase the salt content so it won't be as healthy. ?You could also leave out the meat and add mushrooms, peppers, whatever you like. ?Whatever is in the fridge and needs eating up.
Pasta Bake for the whole family - serves 2 adults plus 1 toddler, would be great (but messy) for baby led weaning, loads of easy to pick up bits
Ingredients
150g Dry pasta twists
1 small courgette cut into thick sticks
Spray oil or olive oil
A small pinch of finely chopped fresh chilli or chilli powder (optional)
150g cooked, chopped chicken
200ml Full fat milk
250g Tomato based sauce for pasta (I used my own recipe which I posted here but you could use your own or, at a pinch, use passata and added garlic)
1 tbsp cornflour
A sprig of thyme or other herbs
80g Strong / Vintage cheddar
Method
Preheat the oven to 200oC / 400F.
Cook the pasta according to pack instructions but drop the cooking time by 1 minute from the minimum. ?So my pack said 10-12 minutes so I cooked it for 9. ?Fry the courgette until starting to brown and add in the tomato sauce and chilli. ?Bring to the boil and add the chicken and thyme to heat though. ?
To make the white sauce, heat the milk in a microwave or saucepan until boiling. ?Mix the cornflour with some cold water then gradually whisk in the mix into the milk heating more to thicken if necessary.
When the pasta is cooked, drain, reserving a couple of tbsp of the cooking water and mix the pasta with the sauce adding a little of that water if needed to slacken the sauce.
Pour into a baking dish and top with the white sauce and grate the cheddar on top. ?Bake for 15-20 minutes or until browned to your liking. ?
Switch off the oven and remove the portion for your baby or toddler (if you have one) and allow to cool until safe for your child. ?The remainder keeps warm pretty well in the cooling oven for the adults.?
Jim gave me a copy of this book, and I immediately dove in. I love it.
For me, there are really three virtual books in this single volume.
The first, is a book about the philosophy of marketing, about connecting with your customers and marketing via exceptional service and engagement with content creation. There are some absolute gems of advice from some really sharp minds that can help anybody at any stage of their business.
The second is a book about the entrepreneurial spirit, how to capture it, and what to do once you?ve caught it. It will tell you about the long nights and the hard work, but it will also tell you about the wonderful satisfaction that comes from doing what you love and calling your own shots.
The third is a how-to guide for internet marketing. How to find and use influence, how to organize your advertising and marketing campaigns, and some great examples of what has worked for some luminaries in the field.
Each virtual book alone would have been worth the price of admission. Instead, you get a complete package for changing your view on marketing and customer service online. You?ve seen the work of those interviewed before, you?ve probably even been swayed by their pitches before. Now you can learn about the thinking and philosophy behind these brilliant entrepreneurs and marketers.
Stop reading this right now and buy the book. You won?t regret it.
Folks currently are starting to know the significance of excellent wellness, which can be accomplished by way of a properly well balanced diet plan, slicing out smoking and drinking, and incorporating some type of physical fitness plan into each day life. Whilst you?ll find some outstanding possibilities such as walking, swimming, tennis, handball, or operating out in the fitness center, yet another option contains Pilates, that has taken our modern society by storm. As well as being entertaining, Pilates is simple within the body even though making excellent outcomes.
Pilates involves a technique of movement coupled with therapeutic physical exercise. This specific fitness system took Joseph H. Pilatu more than 60 many years to fantastic. In addition to helping persons look superior by toning and firming the physique, Pilates makes folks feel better. By way of precision toning and bringing stability to muscle tissues in the joint area, this health method stimulates circulation by utilizing muscular flexibility, proper musculoskeletal alignment, and array of motion.
Pilates also gives far better body consciousness when promoting coordination and producing new neuromuscular patterns. The result of this conditioning system can be a reduction or total elimination of chronic pain and/or injuries or re-injury. Joseph himself grew up with arthritis and asthma, generating him feeble. His father was a prize-winning gymnast and his mom a practicing naturopath. Utilizing a discarded anatomy guide, Joseph researched and researched to superior have an understanding of the various physique components. Through the age of 14, he had learned the way to develop his personal physique, so substantially to ensure that he was hired as an anatomy design for other students to study.
With Joseph?s information and fine-tuning of this physical fitness method, he and his wife started training Pilates. The exciting factor about this health program is the fact that by being created around the all-natural movement of animals along with other natural actions, millions of individuals are able to include the system into their day-to-day lives, getting they look and feel greater. The bottom line is the fact that no matter if utilizing Pilates or some other sort of health, you?ll be able to tone the muscle tissue, bolster joints, and even lower anxiety around the heart and lungs, giving you a longer, healthier lifestyle.
We now see folks from stay-at-home mothers to famous movie stars faithfully employing Pilates with wonderful results. Actually, if you?d like probably the most from conditioning, we suggest you combine Pilates having a cardio type of physical exercise for instance biking, walking, or swimming. In this way, you get the very best of each worlds. Most effective of all, fitness might be done by men and women of all ages and expensive equipment is just not required to be effective. For that reason, should you be weary of seeking and experiencing bad, get concerned with an excellent physical fitness system just like Pilates.
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Prof. M. Scott Boone, Appalachian School of Law Virtual Property and Copyright: Taking the First Sale Doctrine into Virtual Space General concept: apply virtual property/object theories originally developed in connection with virtual worlds to first sale.? Copyright Act speaks of ?property rights in any material object,? ?202, and also ?computer programs,? ?117.? The latter was designed to protect ordinary user rights, starting to capture the idea of a virtual object which isn?t necessarily just one iteration of code sitting in RAM or sitting on the hard disk. The object is the combination of the functional software with the data with the copies in multiple places that together allow the user to do something. That?s the underlying idea anyway.? Those things shouldn?t be treated separately for purposes of infringement, because they work together to create one usable object. Barrier: contracts. A license isn?t a transfer of ownership, and thus first sale doesn?t apply to avoid distribution liability even if there?s no reproduction. One possibility: revise ?109 to add in rightful possessors, or a principle of mutuality?whatever user gets from copyright owner, user can transfer.? Copyright owners argue that they retain power to terminate licenses, even though they never really intend to do so.? Some software might be linked with a service and we wouldn?t want it transferable?might want an exception for such cases where it?s really a personal negotiated relationship instead of a sale of consumer goods. Second problem with contracts: restraint on alienation; can still add a contractual promise not to distribute even if it?s not a license. Barrier: technology.? DRM can prevent transfer; legal restraints on circumvention.? Need ?109 for ?1201? Prof. Thomas C. Folsom, Regent University School of Law Property concepts can change with code: if X sells poisoned flowers and Y doesn?t like the petals drifting over her fence, one must give; but if X can code the flowers to be nonpoisonous unless they leave the property with her permission, then both can win.? Code allows performativeness: can change reality immediately upon utterance.? There should be degrees of coded exceptionalism.? Build code to manage people?s relationships to focal points (Superman, the Eiffel Tower) that shape their decisions. The Magician?s Horse: Designing Code and Other Laws Beyond Cyberspace Prof. Jon M. Garon, Chase College of Law, Northern Kentucky University Legal Education in Disruption: Headwinds and Tailwinds of Technology Disruption: when change is choked off, the ultimate change is even greater and more disastrous.? Disruptive tech, etc.; globalization, pressure on state from ability of individuals to communicate; ability to aggregage/disaggregate info in cloud culture, including Facebook; internet of things, RFID chips; network effects creating real winners and losers from being on or off the dominant system?all triggers for disintermediation.? Globalization is also affecting law; BigLaw is where most people have focused on?huge economies of scale/control are possible so that consolidation of power in corporations is mirrored with law firms providing similar services. His focus: the bottom of the pyramid?software, self-help dramatically changing the environment. 2/3 of legal services have moved to corporate clients, who are more price sensitive. Most model rules are designed to protect the individual against the lawyer; the bargain is not as skewed with 500 lawyers in-house.? Lawyers as gatekeepers to info have fallen out of favor and we?re in a self-help world; costs of legal services have become incredibly difficult to pay and the value proposition is hard to justify if you can research it yourself.? Texas courts tried to block software formbooks but the legislature struck back. We?re only self regulated when the public wants us to be. Money is coming to legal forms: Kleiner Perkins invested $100 million and Institutional Venture Parters invested $41 million in LegalZoom; Google has invested; FindLaw is a ThompsonReuters company, who?s also invested in the leading Indian legal outsourcing company.? Direct legal services and mediating access to the public?not just a little WestlawNext app. Small is also big: models of socially mediated/curated legal forms are becoming popular; some are free/nonprofit and others proprietary; many use as loss leader.? LegalZoom is being attacked on the bottom--$99 is too expensive for incorporation, we can do it for $34.? Virtual law firm: ex-BigLaw lawyers are connecting virtually through software portals, getting rid of physical overhead; being used by AmLaw 500 companies. This is the wave of middle corporate law firm access, creating new relationships with attys.? New practice guides/ethics rules are emerging. These strategies are being adopted by lawyers but not being taught in law school.? We?ve always decried the end of the profession, but there are changes: modern client wants 24/7 service, without jurisdictional boundaries, very fast. This creates specific dangers for lawyes who need time to think: there?s an ethical constraint on how fast we can work. Thus prepackaged solutions prepared in advance are ethically responsible. Law school market shift: 45,000 students will graduate in an average year, to 25,000 jobs requiring a JD.? We?re producing to an eroded market.? Lawyers must be tech savvy, networked, specialized, unbundled, scalable. To do it well: socially responsible, civically engaged; work-life balance; valued intermediaries providing highly personalized consultative advice.? Legal education teaches content, and some skills?fact investigation, negotiating, client counseling.? Not enough of curriculum is directed towards corporate client practice instead of litigation; we don?t teach how to operate as businesspeople or how to talk to businesspeople.? Core curriculum has to be taught: people need to understand fundamental legal content.? But we should teach critical reasoning and analysis as a course, rather than inferring skills from 1200 page casebook.? Experiential learning?clinics, field placements, simulations, reflective learning from summer jobs/in-house, etc.? We must also pull skills from MBA programs: at a minimum, organizational behavior, management and leadership.? Quantitative and qualitative skills are also important. Prof. David S. Levine, Elon University School of Law Bring in the Nerds: Secrecy, National Security and the Creation of Intellectual Property Law We have no idea what?s happening internationally; compared to international lawmaking, Congress is transparent!? Observation one: secret law is not law.? The ability to see sausage-making on the international stage: FOIA has a national security exemption.? The rubric through which int?l IP law is running currently is ?national security.?? This isn?t based on the anecdotal data that piracy sometimes funds terrorism; the concern at issue here is one of diplomatic relations/effective int?l negotiations.? The ability to negotiate without the public glare; he is not suggesting that all int?l negotiations should be completely transparent and documented.? His concern is that there are fundamental info asymmetries between certain corporate entities with access to the USTR through an administrative process and others.? And the info at issue is the basic negotiating text, which is not known to the public but is known to representatives from content industries. Current executive order includes a variety of topics: national security information, including foreign gov?t info (where IP law tends to fall?draft text has info contributed by other countries); intelligence activities; foreign relations of the US including confidential sources; scientific matters relating to national security; nuclear safeguards; system vulnerabilities; WMDs.? WMDs should probably not be treated in the same way as draft texts about IP law. The impact is severe: ACTA.? Draft FAQ, retrieved through FOIA, included ?What if U.S. positions evolve during negotiations??? ?A: The public can see how the U.S. position has evolved when the final text is signed.?? With regard to the Transpacific Partnership agreement: US says it will disclose this four years from entry into force of the TPP agreement, or four years from the close of negotiations if no agreement enters into force.? If TPP never becomes law, the public will still not know what the negotiations look like for 4 years.? Why does this need to be withheld? We know more about Russia?s ICBMs than about the US position on TPP. Observation two: transparency, accountability and public input. We need nerds to avoid poorly drafted and unbalanced law?see, e.g., SOPA/PIPA and the DNS provisions. FOIA needs to be reconfigured to be more about when public inputs to government are needed; difficult to apply ?right to know? in abstract when competing with significant concerns on the other side.? Transparency is important when an expert would need to know more to opine.? Strong right/presumption for US negotiation texts and other information. Prof. Deborah Tussey, Oklahoma City University School of Law Work for Hire, Work for Free: The Dilemma of the Digital Freelance Background: Lawsuits by HuffPo bloggers; direct dissemination by authors; crowdfunding; voluntary contributions on wikis; worries about getting paid less online.? Is WFH fair, and is it well adapted to a changing environment?? Her focus: Freelance contributors to collective works in the industries most specifically benefited by WFH.? Including revision rights and license interpretation.? Excluding academics and sound recordings. Freelancers? rights get determined at initial allocation, and then subsequently exploitation under license?new uses/new media. Law is written by/for publishers at both stages.? Justified as necessary to facilitate investment in and exploitation of collectively produced works.? Concerned with freelancers and ?employees by interpretation??people who get called employees because of CCNV.? Some special commissions are voluntarily negotiated WFH agreements (Spike Lee directing Malcolm X) and others are involuntary?former employees who?ve been downsized and turned into workers for hire. Consequences may, of course, be severe for rights/duration/termination.? If a freelancer stays out of WFH, new media uses become an issue.? Tasini tried to protect freelancers by excluding electronic republication from the statutory privilege, but this was easily nullified by standard form contracts.? Publisher holds the cards.? Proposals for rectifying this: abandon agency rules as inappropriate; rejigger CCNV and import concepts of informed consent from employment law; encourage authors to organize and collectively bargain.? Intrigued by importing concepts from civil law: generally start from basic rule that employees don?t lose their copyrights, corporations can?t be authors. Then they limit transfers, require writings and specifically enumerated grants; narrowly construe grants; provide statutory royalties.? Intriguing but will Congress take lessons from Europe?? The reality of freelancing: highly variable rewards (makes academic writing look nice). Many writers? organizations are out there, hugely diverse by sex, genre, ethnicity, medium, etc.? Also lots of networking sites.? Some are actual unions engaging in collective bargaining; others offer services including contract review. There are some collective licensing societies.? Copyright tends to lump these folks into a few categories, but freelancers sort themselves more carefully. This might impair collective action, but also indicate problems with copyright?s treatment.? A lot of experimentation with new business models?pay what you want; direct dissemination. A fair number of positions are unpaid, as with HuffPo. Maybe we need distinctions between the kinds of works and/or industries that will likely remain in centralized production mode.? We?re used to centralized studio system for movies, but tools are now available to decentralize.? Could also take differences in creativity into account: contributor to a case report in a database might not deserve copyright, but a contributor of an article to a magazine is different.? May need less incentives for publishers/aggregators as individuals start their own dissemination. Maybe employee should just mean full-time employed, salaried workers.? For non-salaried contributors, they should keep copyright and we should focus on exploitation, taking lessons from civil law countries and deal with licensing as a way to even up the balance. Greg Vetter: we now regulate medical records software?to get federal funding you have to make ?meaningful use,? which is really tightly regulated.? Is this what Folsom is talking about? A: if we look at code world as network that affects living organisms, that can lead us to the right questions. My q: The last three presentations are all about crony capitalism: we live in a world where the winners win big and the costs are outsourced to the individuals on the bottom; tournament structure.? Three different strategies suggested?live with it and help the winners win; top down reform; and something else that might include bottom-up reform. Garon: the bar?s inclination is to protect us from these changes, and it?s been ineffectual; the legal profession is not going to have exceptionalism that will keep competitors out.? The rise of internationalization, WTO, etc.?the model that suggests that we can hold onto our piece of the pie is na?ve. My fiduciary duty to my students: be transparent with them. Levine: Not attempting to delude himself about the role of public choice. Trying to take the actors and assume that they?re operating in good faith.? Has no doubt that campaign finance is the fundamental issue here.? Even if we solve that, there are still info asymmetries?let?s take seriously that policymakers want to make right decisions and look at structural impediments. Most of these decisions are vested in the executive, and you need to resolve procedural/administrative issues. Tussey: WFH is what it is because publishers got it in the 1976 Act.? Freelancers have been at their mercy for a while, and she is not terribly hopeful that will change.? More hopeful that changes in tech may accomplish some things as works are capable of being produced and disseminated directly to their public. Garon: Freelancers provide an interesting forum for collective bargaining; theater and sound recordings have been very heavily negotiated and aren?t in WFH, which illustrates that collective organizations can perform quasi-legislative functions.? Getting all the actors in the room makes a difference, as Levine suggested. Levine: Rep. Issa?s alternative to SOPA/PIPA?public suggestions for the bill. Boone: would also say his project is tied to this?big copyright owners v. the consumer.? If you look at history of first sale, you see a shift/reversal of roles. Copyright owners traditionally fought to hinder secondary markets, like used CDs, VCR rentals. But if the change in the method of distribution leads to getting rid of secondary markets, then it?s the users who need to seek legislative assistance and legalize secondary markets. Sapna Kumar: FOIA change for priority when input to the government is most needed.? Who would make that decision? You don?t want it to be the agency itself?they?ll think they already got the necessary input.? Agencies don?t invest much in FOIA answers. Levine: tech is changing the ability of government to respond more quickly and thoroughly, though e-government has been largely defunded.? Bigger theoretical question is who decides?he?s thinking about how to define the factors. Things like whether there?s a collective interest at issue.? When there?s a specific body of experts with something to provide.? Not trying to eliminate the right to know! Katja Weckstrom: First sale and TM?? Also, for Folsom, beware of legislation?not that great at fine-tuning technical solutions. Boone: What would it mean to look at first sale in TM? Weckstrom: in copyright, contracts are a vehicle to profit from consumer?s use; in TM, this is usually not the case.? Usually no contractual relationship between TM owner and user.? (Compare FB?s new user agreement claiming rights over ?Face? and ?Book.?)? So on that model ability to control market is less; also no DRM. Boone: He?s focused on areas dominated by copyright rights?ebooks, games. Levine: legislative support for the change might come from TM concepts like nominative fair use?it?s ok to sell a legitimate copy--that?s worked very well for hundreds of years. Folsom: yes, skeptical of legislative competence.? He proposes a rule of thumb that any institution can apply. He doesn?t like statutes that become outdated by the time the legislature acts?too much specificity. He wants a rule more like TM, kind of fuzzy. A. Christal Sheppard: Industries say they won?t participate if their comments aren?t private. Levine: he?s skeptical of this. Diebold says that it won?t sell voting machines if it has to be public in a state; a state says no; turns out Diebold wants to be in that market enough to comply!? His response: let?s find out; we know that we?re not getting good law with this flawed process. If you want to be in the room, you?re going to have to deal with the process. Yu: For Levine: Your proposals aren?t very nerdy, but rather legal: is there a nerdy proposal? For Garon: what?s the IP hook? Levine: yes, his proposal is relatively un-nerdy. Could do more with info formatting. Could also put nerds on consultation communities, but FOIA is just not even grappling with these issues. Garon: for Boone, maybe the proposal is strongest when DRM works: you?ve converted the work into an object, and then ?109 rights should apply. Boone: agrees; his paper goes into the theory of the virtual object.? You have to regulate both DRM and contract, since either can allow the copyright owner to prevent a secondary market. That?s asking a lot, so we ask if we really need a secondary market.
[unable to retrieve full-text content]Cause Marketing: A Win-Win for Small Businesses and Nonprofits, a free webinar from Ventureneer, shows nonprofit leaders and small business owners how to help each other increase visibility, build community, and ...
ScienceDaily (Mar. 28, 2012) ? The Philadelphia Phillies, St. Louis Cardinals and Arizona Diamondbacks should win their divisions, while the Atlanta Braves and the Cincinnati Reds will make it to Major League Baseball's post-season as wild card teams in the National League (NL) in 2012, according to NJIT's baseball guru Bruce Bukiet. The San Francisco Giants, Milwaukee Brewers and Florida Marlins could be close on the heels of the Reds and Braves but should miss out on the post-season by 3 or 4 wins. For more than a decade, Bukiet, an associate professor and associate dean, has applied mathematical analysis to compute the number of regular season games each Major League Baseball team should win.
Though his expertise is in mathematical modeling, rather than baseball, his projections have compared well with those of so-called experts over the years.
This year, he says that in the American League (AL), the New York Yankees, the Detroit Tigers and the Texas Rangers should repeat as division champions, while the Boston Red Sox and Los Angeles Angels should be the wild card teams. "In the AL, the competition for the wild card shouldn't even be close," Bukiet says. "The next best team, the Tampa Bay Rays, should win 9 less games than the 93 games both the Red Sox and Angels should win," he adds.
Bukiet makes these projections to demonstrate and promote the power of math. He wants to show young people that math can be fun, that it can be applied to improve one's understanding of many aspects of life and that if you love mathematics, it can be a great college major and lead to a satisfying career.
Bukiet bases his predictions on a mathematical model he developed in 2000. He has made various revisions over the years. His results have led to back-to-back wins as predictions champ at baseballphd.net in 2010 and 2011. More results concerning his baseball modeling can be found at http://m.njit.edu/~bukiet/baseball/baseball.html.
In the NL East, the race for first place should be tight with the Phillies repeating as division champions, winning 92 games and the Braves just two games behind at 90, with both teams making the playoffs. (The model predicted the exact same number of wins for these teams in 2011, but the Braves won just 89 games and missed the playoffs by a single game.) In the Central Division, the St. Louis Cardinals should win 94 games, the most in the National League, while the Reds should win 87 and be the NL team that makes the playoff under the new system in 2012 in which 5 teams in each League go on to the post-season. In the West, the Arizona Diamondbacks should repeat as champions with 88 wins.
The New York Yankees (of the AL East) and Texas Rangers (of the AL West) should tie for the best record in baseball with 97 wins. They should each be 4 games better than the second-place Boston Red Sox and Los Angeles Angels, respectively.
Bukiet should have plenty of time this summer to spend doing math since his favorite team, the New York Mets, should come in last place in their division, the NL East, winning just 72 games. His only consolation is that there should be 7 teams with even worse records, with the Minnesota Twins earning the least wins of any team (64). And once again, for the 20th year in a row, the Pittsburgh Pirates should finish with a losing record. Their 68 wins are well below the 81 wins needed to break their famous streak.
Bukiet expects the AL win totals at season's end to be as follows:
AL East: Yankees -- 97; Red Sox 93; Rays -- 84; Blue Jays -- 80; Orioles -- 67.
AL Central: Tigers -- 96; White Sox -- 82; Indians -- 78; Royals -- 70; Twins -- 64.
I?ve thought a great deal about my friends this week. And the first song on the radio this morning was Tracy Lawrence?s star filled ?Find Out Who Your Friends Are.?
Never stop to think ?what?s in it for me?? or ?it?s way too far? They just show on up with their big old heart You find out who your friends are
There is so much to enjoy about this stage of my life. The friends we have are not necessarily the ones I expected to have?10, 12, 15 years ago. But I am not the person I expected to be either.
Growing up I knew many people, hung with many different crowds. But I prefer one-on-one relationships and interaction. I?ve had my share of best friends. Friendships have to evolve or I think they become toxic. If you had asked me my freshman or sophomore year of high school if there was a chance me and my bestie?would ever stop talking, I would tell you ?No way.? But we did just two short years later. All the high school drama and realizations we were going in different directions (and boys) came between us. We hadn?t spoken?in almost 20 years?after being almost inseparable for 5 years.
I?m having lunch with her, her mother, and her children (mine will be in school) next week.
I can?t say reconnecting with her has been just ?like picking up where we left off? because in all honesty, I?m not 18 and neither is she. But it has been encouraging and enjoyable because we did change. I think we have a mutual respect, a fondness for those 5 years, and the maturity of the past 20 years that is bringing us together. Oh sure, what high school experience wouldn?t be complete without friend drama but I think it would be even sadder to have ?stuck together? for 20 years and then have a falling out.
In college, I had roommates. I had close friends but I also had the beginning of my relationship with DH. Besties?weren?t a priority. I also had relationships with the women at the church I attended. I was treated like an adult but also like a younger sister. I watched and admired them, nannied for them, and I desired what they had?sisterhood.
Life didn?t turn out the way I had imagined. The friendships that we form?early in life are subject to the changes that happen in circumstance, in maturity, in life. Often when there is a disparity?of maturity, relationships can become toxic or unfulfilling. I?ve seen both.
In the first, DH has always been a mature person?I joke he?s finally catching up to his real age (and now reverting!). It tended to make me more mature, more less wanting to play games. There is nothing more sad than being a play group and Cheerleader Barbie is still trying to be the same person she was in high school and play the same games.?Or the relationship tends to be one-sided and work it takes to make the relationship last is just too much. Cheerleader Barbie probably didn?t even notice when I stopped going to play group but other relationships ended a bit more messy.
In the second, I?m still waiting for that sisterhood. This has much to do with life circumstances. The women who are staying at home are mostly retired, with grandchildren? and not still raising preteens. And yet DH and I are closer to his retirement than most of my high school classmates. I?ve found the closest friendships with the ones our age but that started having children and careers early and have that bonus baby the same age as our children. But it is rare indeed, at least where we live.
So, to my surprise, my close relationships now have come from involvement in the children?s activities, outside of church. This is always a gamble (remember Cheerleader Barbie?) but I?ve been blessed with several close friends that I have ?matured with.? I?m not talking about aging. I?m talking about that ?ah-ha? moment when you realize we?re friends because we are, not our children, and then those relationships survive even if our children no longer have mutual activities or even get along. I have one friend from play group who I?ve stuck with even beyond our move, because even though we met over our little rug rats, we built our relationship first. Besides, she let me come to her 40th birthday party dressed as Tonks. She has been there for me through so much. I know she?s going through some things right now that really make me wish I was closer, wish I could help.
My other friends, the ones who go with me scrapbooking, they are the ones who have let our relationships evolve beyond our children. They are ones who I call to take care of my children in emergencies. They are the ones who have looked the other way when I decided to live a little filter-free there for a while, because they knew what was going on and not that I was wanting Cheerleader Barbie drama. Unfortunately, even though I know I?ve got to take care of myself physically and emotionally I take pride in being able to be there for my friends when they need ME and?I really haven?t been able to do that. I am on the mend in many ways. No, we?re still trying to find the right drug protocol but in the big picture, compared to what others are going through, this is small and could always be worse.
I may not have those close ?sisterhood? relationships (yet)?but I do think God put?us in a position to be an example to others. Maybe I?ll remember this when I see a 20 something in need of a ?sister? and help her to learn she can have (and needs)?friends beyond her children. In the meantime, I hope to take this Bench Message to heart again and do more of Being a Friend now that I?m getting better.
If you want to write on this topic and have your blog linked up to mine, send me a comment and I?ll make it happen!
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I am married to a member of the U.S. Merchant Marine. Specifically, married to a Chief Engineer. Thus the name Snipe Wife. While in some circles "Snipe" is a derogatory term for engineers, I use it with pride and affection. Ours is not a unique situation but it is far less common than most. This is for everyone who asks me what is the Merchant Marine and how do I handle the "life."
There are many things changing in small business marketing today: new partnerships between larger and smaller businesses and new marketing mediums like text messaging with which to contend. Here are some links on the latest to point the way.
Meditations for Startups
Big firms can point the way. If branding and marketing aren?t your company?s strong point, perhaps a mentor from big business can help. These companies found big time advisers eager to lend a hand. WSJ
New channels offer new opportunities. Take text messaging and the chance to reach a whole new audience with immediacy. If you need tips on how to wield this new marketing tool, here they are. Entrepreneur
Finding Your Center
Knowing what you do is key! Susan Oakes delivers a post on what should be the easiest question for any small business owner to answer. If you can?t answer it simply, make this the first step of your marketing journey. M4B Marketing
Not all e-mail marketing is created equal. If you have an e-mail marketing campaign that doesn?t seem to be working, sometimes a simple diagnostic can help. Check the list of simple mistakes. Pitney Bowes
Harnessing Positive Energy
Don?t be afraid to be yourself. When marketing your business, understand you cannot be all things to all people. Here?s how to let your true personal brand shine through. Marie Forleo
Communication opens doors. If you aren?t communicating with customers or clients, then all your efforts are in vain. How can you make any progress at all without rolling up your sleeves and giving it your best effort? Seth Godin?s Blog
Achieving Balance
Keep your focus in social media. Social media may be easy to use, but putting it to work effectively for your business takes time, imagination and focus. Consider some simple starting points. FixCourse
Don?t be a twit about Twitter. Used correctly, it can be a tremendous tool for your small business. How can you make the most of those 140 characters and how do you build the following needed? Saying It Social
Focusing Inward
Always have a unique voice. One of the best ways to do this these days is through your company blog. But the first step may be to be sure your blog has a distinctive style all its own. BusinessTips.ph
Create great customer experience. This is probably the tallest order your small business has to fill, but it might ultimately be the most important. How can you make sure you?re doing your best? Startup Professionals Musings
Keep in mind, generally these choices can be found, and usually they?re not. Chat together with your present cheap auto insurance coverage business, or even a fresh automobile insurance protection company in which you?re looking at doing enterprise, and enquire about ways to get low-cost automotive insurance coverage pertaining to convicted individuals. However, there is a problem with acquiring an auto policy from info you get within adertisements. Every single insurer says that they could provide the most affordable prices, greatest service, and fastest claims processing! How do you know which company will definitely be right for you?
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There are many certified lawyers on the market who just might help you. As outlined by studies, California auto insurance quotes claims have a much better chance of staying settled when it is done with the assistance of an auto insurance professional lawyer. This is because your auto insurance lawyer knows every miniscule detail there is to know regarding auto insurance claims. Shield your rights; hire an automobile insurance lawyer to assist you. These companies are knowingly and willingly contending towards one other for the company. Subsequently the customer can safely believe they?ll find aggressive car quotes via each business. Subsequent, the customer will select each business they?re considering getting a estimate from. Motor vehicle insurance side by side somparisons are now provided for the buyer to choose on the web.
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An alleged Magenta-branded memo's managed to find its way out of store lockup and land at the TmoNews offices, revealing some not-so-good news for potential future customers. Per the leaked document, T-Mobile's about to hike the price on its 5GB and 10GB Promotional Bundles data plans, starting as soon as April 4th. The changes would slap an extra $5 monthly fee on each Classic plan, boosting the 5GB to $35 / $40 and the 10GB to $65 / $70, however it'd only apply to customers signing up after the aforementioned April date. Perhaps, it's all part of T-Mo's "restructuring" plan...
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Oh My: Customer Funds Unlawfully Used To Cover MF Global's Debt Per Direct Order of John Corzine, Email Says
MF Global went $200 million into overdraft for its own firm business (its own accounts, its own profits) and I guess they didn't have the money to cover that.
So what did they do? They sent JPMorgan customer monies, which are supposed to be segregated and cannot, of course, be used for the firm's own business. That would count as an "involuntary loan," and if it's not paid back, and "involuntary taking." Like if I need my neighbor's car, for example. And just happen to maybe take it out a few nights a week. And then I sold it for hookers & action figures. Like: Theft. This was so rank that JPMorgan wrote back for written reassurance that these funds were the firms', and not MF Global's. MFGlobal did not write back. It ignored the letter. So, they knew what they were doing was wrong. It was not a mistake. They needed cash so they swiped some from clients. Which was then lost. At Hot Air: Corzine claimed in his sworn testimony he "never" instructed anyone to use client funds for his own uses. Care to amend that testimony, JC? If this $200 million was swiped and "vaporized," I think I have a suspicion about the fate of the full $1.2 billion. Steal little, steal big. (Did I just say stealing $200 million was stealing little?) Posted by: Ace at 07:42 PM
If you are affected by low sales online, you can simply turn the tables by utilizing video marketing . Video marketing can change many things for small firms as well as already-established brands. If you would like to take advantage from video marketing, you've got to make sure you are using different tools to boost visibility of your online videos. Except for that, you also have to ensure you are finding out about video S.E.O since it can boost your video marketing campaigns simply.
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Infrequently, people use SEO systems and they forget the seriousness of content. If your mpegs lack fine content, they won't rank notwithstanding your SEO efforts. YouTube and Google closely observe social activity for ranking videos. If your mpegs lack good content, they will fail to generate any social activity. Thus, you will not get good ranking for your movies.
To achieve results from video marketing for small business, you've got to make sure that you are using YouTube. YouTube is a good place for video marketing. To find a neat place among YouTube results, you have to make sure you are concentrating on YouTube. You have got to understand YouTube analysing and find out about all the metrics to interpret the data.
If you focus on video marketing for small business, you have got to make certain that you know the essential rules of SEO. You can simply use these rules to lift the visibleness of your mpegs on YouTube and search engines. This is going to help you to reach your required audience swiftly.
Greg Dickson gives useful tips for video marketing. Small businesses relying on video marketing for small business can find many useful tips and tricks here. You will find it easy to learn how meta data influences video SEO apart from mastering YouTube analytics. UK Video Marketing has it all.
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NEW YORK, March 20, 2012 /PRNewswire-USNewswire/ -- Spring officially begins today and, while this winter's mild, dry conditions have reduced the likelihood of severe flooding events caused by melting snow in some parts of the country, it has not eliminated the risk of flooding caused by rain, hurricanes or other disasters, according to the Insurance Information Institute (I.I.I.).
Homeowners, renters, and business owners should consider purchasing a flood insurance policy, or renewing an existing one. Just last August, Hurricane Irene resulted in flood conditions with rivers and streams rising to record levels in 10 states. Floods are one of the most common hazards in the United States. Some develop slowly while others, such as flash floods, can materialize in minutes. Moreover, floods can be both very local, impacting a single neighborhood or community, or very large, affecting multiple states.
Unfortunately, the number of people financially protected by flood insurance is still very low, and getting lower. A 2011 poll by the I.I.I. found that 14 percent of American homeowners had a flood insurance policy, up from 10 percent in 2010 but still below the 17 percent who said they purchased flood insurance in 2008. The percentage of homeowners with flood insurance was highest in the South, at 19 percent, up from 14 percent in 2010 and back to the level of 2009. Thirteen percent of Midwestern homeowners had a flood insurance policy in 2011 along with 12 percent of homeowners in the West and 5 percent in the Northeast.
Flood coverage is excluded under standard residential insurance policies as well as under many commercial property insurance policies. Coverage for flood-caused damage is available from the federal government under FEMA's National Flood Insurance Program (NFIP), and from a few private insurers.
Flood damage to cars is covered under the optional comprehensive portion of a standard auto insurance policy.
The NFIP's flood insurance policies cover direct physical losses caused by flood as well as losses resulting from flood-related erosion caused by heavy or prolonged rain, coastal storm surge, snow melt, blocked storm drainage systems, levee or dam failure, or other similar causes. NFIP policyholders can be covered for up to $250,000 for damages to building property on a replacement cost basis and for a maximum of $100,000 in damages to personal property (contents) on an actual cash value basis. Replacement cost coverage pays to rebuild a structure as it was before the damage. Actual cash value is replacement cost, minus the depreciation in value that occurs over time. The average NFIP flood claim has over the past decade amounted to over $33,000, the NFIP reports.
There is a 30-day waiting period?from date of purchase?before a new NFIP policy goes into effect, so it is important to buy your policy ahead of time.
The NFIP paid out $1.1 billion in flood claims to policyholders who incurred damages after Hurricane Irene slammed the Atlantic seaboard in late August 2011, FEMA data indicates.
Since the NFIP was created by Congress in 1968, 25 to 30 percent of all paid NFIP claims were for damages incurred in communities not officially designated at the time of the flood as a special flood hazard area. NFIP coverage is available outside high-risk zones at a lower premium. Consumers can get more information by visiting the NFIP's FloodSmart website. The site has tools that can tell you approximately what your risk of flooding is, and estimate how much a policy will cost.
Private flood insurance is available for those who need additional insurance protection, known as excess coverage, over and above the basic NFIP policy limits, or for people whose communities do not participate in the program. In addition, some insurers have introduced special policies for high-value properties; these policies may cover homes in non-coastal areas and/or provide enhancements to traditional flood coverage.
"Just because most of the United States had dry and mild winter weather doesn't mean flood risks have altogether disappeared," said Michael Barry, vice president, Media Relations, I.I.I. "Largely due to the limited winter snowfall, for the first time in four years, no area of the country faces in 2012 a high risk of major to record spring flooding, according to the federal government. But some states have still been deemed as being at above-normal risk of flooding."
"The Ohio River basin, including portions of Illinois, Indiana, and Kentucky, along with parts of Louisiana and Mississippi are the only areas [of the U.S.] with an above-normal risk of flooding as soil moisture and river levels are currently above normal. Additionally, odds favor above-average April rainfall for the Ohio River basin," the National Oceanic and Atmospheric Administration (NOAA) stated last week in its 2012 Spring Outlook, an assessment the agency produces annually.
(Source:?InsuranceNewsNet.com)
Call Salzberg Insurance for a Virginia Flood Insurance Quote today!
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Case studies have the substantial advantage that they can easily be checked for factual errors with the business concerned. The actual SEO Experts in a good SEO company will help within increasing traffic for your website thereby adding to its popularity and business. Usually prefer the businesses that make use of white hat actions.
SEO is the short form of Search Engine Optimization, which is a process that occurs inside a search engine when it?s trying to find key phrases with related websites. The competition is actually greater, nevertheless, now that the majority of businesses possess moved onto this system to promote their ventures. This helps you to get the desired people to this site leading to more business for you, therefore profits.
The internet has become a extremely popular marketing medium to many businesses. These articles, which are written by their devoted team of writers, tend to be submitted to numerous article directories. These services are either supplied individually or could be packaged, and packages have more than one service in them and are used by many big corporations.
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Computer model of spread of dementia can predict future disease patterns years before they occurPublic release date: 21-Mar-2012 [ | E-mail | Share ]
Contact: Richard Pietzak riz2008@med.cornell.edu 212-821-0560 New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Weill Cornell scientists say the program might help patients manage their disease
NEW YORK (March 21, 2012) -- Researchers at Weill Cornell Medical College have developed a computer program that has tracked the manner in which different forms of dementia spread within a human brain. They say their mathematic model can be used to predict where and approximately when an individual patient's brain will suffer from the spread, neuron to neuron, of "prion-like" toxic proteins -- a process they say underlies all forms of dementia.
Their findings, published in the March 22 issue of Neuron, could help patients and their families confirm a diagnosis of dementia and prepare in advance for future cognitive declines over time. In the future -- in an era where targeted drugs against dementia exist -- the program might also help physicians identify suitable brain targets for therapeutic intervention, says the study's lead researcher, Ashish Raj, Ph.D., an assistant professor of computer science in radiology at Weill Cornell Medical College.
"Think of it as a weather radar system, which shows you a video of weather patterns in your area over the next 48 hours," says Dr. Raj. "Our model, when applied to the baseline magnetic resonance imaging scan of an individual brain, can similarly produce a future map of degeneration in that person over the next few years or decades.
"This could allow neurologists to predict what the patient's neuroanatomic and associated cognitive state will be at any given point in the future. They could tell whether and when the patient will develop speech impediments, memory loss, behavioral peculiarities, and so on," he says. "Knowledge of what the future holds will allow patients to make informed choices regarding their lifestyle and therapeutic interventions.
"At some point we will gain the ability to target and improve the health of specific brain regions and nerve fiber tracts," Dr. Raj says. "At that point, a good prediction of a subject's future anatomic state can help identify promising target regions for this intervention. Early detection will be key to preventing and managing dementia."
Tracking the Flow of Proteins
The computational model, which Dr. Raj developed, is the latest, and one of the most significant, validations of the idea that dementia is caused by proteins that spread through the brain along networks of neurons. It extends findings that were widely reported in February that Alzheimer's disease starts in a particular brain region, but spreads further via misfolded, toxic "tau" proteins. Those studies, by researchers at Columbia University Medical Center and Massachusetts General Hospital, were conducted in mouse models and focused only on Alzheimer's disease.
In this study, Dr. Raj details how he developed the mathematical model of the flow of toxic proteins, and then demonstrates that it correctly predicted the patterns of degeneration that results in a number of different forms of dementia.
He says his model is predicated on the recent understanding that all known forms of dementia are accompanied by, and likely caused by, abnormal or "misfolded" proteins. Proteins have a defined shape, depending on their specific function -- but proteins that become misshapen can produce unwanted toxic effects. One example is tau, which is found in a misfolded state in the brains of both Alzheimer's patients and patients with frontal temporal dementia (FTD). Other proteins, such as TDP43 and ubiquitin, are also found in FTD, and alpha synuclein is found in Parkinson's disease.
These proteins are called "prion-like" because misfolded, or diseased, proteins induce the misfolding of other proteins they touch down a specific neuronal pathway. Prion diseases (such as mad cow disease) that involve transmission of misfolded proteins are thought to be infectious between people. "There is no evidence that Alzheimer's or other dementias are contagious in that way, which is why their transmission is called prion-like."
Simple Explanation for Clinically Observed Patterns of Dementia
Dr. Raj calls his model of trans-neuronal spread of misfolded proteins "very simple." It models the same process by which any gas diffuses in air, except that in the case of dementias the diffusion process occurs along connected neural fiber tracts in the brain.
"This is a common process by which any disease-causing protein can result in a variety of dementias," he says.
The model identifies the neural sub-networks in the brain into which misfolded proteins will collect before moving on to other brain areas that are connected by networks of neurons. In the process the proteins alter normal functioning of all brain areas they visit.
"What is new and really quite remarkable is the network diffusion model itself, which acts on the normal brain connectivity network and manages to reproduce many known aspects of whole brain disease patterns in dementias," Dr. Raj says. "This provides a very simple explanation for why different dementias appear to target specific areas of the brain."
In the study, he was able to match patterns from the diffusion model, which traced protein disbursal in a healthy brain, to the patterns of brain atrophy observed in patients with either Alzheimer's disease or FTD. This degeneration was measured using MRI and other tools that could quantify the amount of brain volume loss experienced in each region of the patient's brain. Co-author Amy Kuceyeski, Ph.D., a postdoctoral fellow who works with Dr. Raj, helped analyze brain volume measurements in the diseased brains.
"Our study demonstrates that such a spreading mechanism leads directly to the observed patterns of atrophy one sees in various dementias," Dr. Raj says. "While the classic patterns of dementia are well known, this is the first model to relate brain network properties to the patterns and explain them in a deterministic and predictive manner."
###
The study's third contributing author is Michael Weiner, M.D., professor of radiology at the University of California at San Francisco, and the principal investigator of the Alzheimer's Disease Neuroimaging Initiative, funded by the National Institutes of Health.
The study was funded by the National Institutes of Health. None of the authors have any competing financial interest to disclose.
Weill Cornell Medical College
Weill Cornell Medical College, Cornell University's medical school located in New York City, is committed to excellence in research, teaching, patient care and the advancement of the art and science of medicine, locally, nationally and globally. Physicians and scientists of Weill Cornell Medical College are engaged in cutting-edge research from bench to bedside, aimed at unlocking mysteries of the human body in health and sickness and toward developing new treatments and prevention strategies. In its commitment to global health and education, Weill Cornell has a strong presence in places such as Qatar, Tanzania, Haiti, Brazil, Austria and Turkey. Through the historic Weill Cornell Medical College in Qatar, the Medical College is the first in the U.S. to offer its M.D. degree overseas. Weill Cornell is the birthplace of many medical advances -- including the development of the Pap test for cervical cancer, the synthesis of penicillin, the first successful embryo-biopsy pregnancy and birth in the U.S., the first clinical trial of gene therapy for Parkinson's disease, and most recently, the world's first successful use of deep brain stimulation to treat a minimally conscious brain-injured patient. Weill Cornell Medical College is affiliated with NewYork-Presbyterian Hospital, where its faculty provides comprehensive patient care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. The Medical College is also affiliated with the Methodist Hospital in Houston. For more information, visit weill.cornell.edu.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Computer model of spread of dementia can predict future disease patterns years before they occurPublic release date: 21-Mar-2012 [ | E-mail | Share ]
Contact: Richard Pietzak riz2008@med.cornell.edu 212-821-0560 New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Weill Cornell scientists say the program might help patients manage their disease
NEW YORK (March 21, 2012) -- Researchers at Weill Cornell Medical College have developed a computer program that has tracked the manner in which different forms of dementia spread within a human brain. They say their mathematic model can be used to predict where and approximately when an individual patient's brain will suffer from the spread, neuron to neuron, of "prion-like" toxic proteins -- a process they say underlies all forms of dementia.
Their findings, published in the March 22 issue of Neuron, could help patients and their families confirm a diagnosis of dementia and prepare in advance for future cognitive declines over time. In the future -- in an era where targeted drugs against dementia exist -- the program might also help physicians identify suitable brain targets for therapeutic intervention, says the study's lead researcher, Ashish Raj, Ph.D., an assistant professor of computer science in radiology at Weill Cornell Medical College.
"Think of it as a weather radar system, which shows you a video of weather patterns in your area over the next 48 hours," says Dr. Raj. "Our model, when applied to the baseline magnetic resonance imaging scan of an individual brain, can similarly produce a future map of degeneration in that person over the next few years or decades.
"This could allow neurologists to predict what the patient's neuroanatomic and associated cognitive state will be at any given point in the future. They could tell whether and when the patient will develop speech impediments, memory loss, behavioral peculiarities, and so on," he says. "Knowledge of what the future holds will allow patients to make informed choices regarding their lifestyle and therapeutic interventions.
"At some point we will gain the ability to target and improve the health of specific brain regions and nerve fiber tracts," Dr. Raj says. "At that point, a good prediction of a subject's future anatomic state can help identify promising target regions for this intervention. Early detection will be key to preventing and managing dementia."
Tracking the Flow of Proteins
The computational model, which Dr. Raj developed, is the latest, and one of the most significant, validations of the idea that dementia is caused by proteins that spread through the brain along networks of neurons. It extends findings that were widely reported in February that Alzheimer's disease starts in a particular brain region, but spreads further via misfolded, toxic "tau" proteins. Those studies, by researchers at Columbia University Medical Center and Massachusetts General Hospital, were conducted in mouse models and focused only on Alzheimer's disease.
In this study, Dr. Raj details how he developed the mathematical model of the flow of toxic proteins, and then demonstrates that it correctly predicted the patterns of degeneration that results in a number of different forms of dementia.
He says his model is predicated on the recent understanding that all known forms of dementia are accompanied by, and likely caused by, abnormal or "misfolded" proteins. Proteins have a defined shape, depending on their specific function -- but proteins that become misshapen can produce unwanted toxic effects. One example is tau, which is found in a misfolded state in the brains of both Alzheimer's patients and patients with frontal temporal dementia (FTD). Other proteins, such as TDP43 and ubiquitin, are also found in FTD, and alpha synuclein is found in Parkinson's disease.
These proteins are called "prion-like" because misfolded, or diseased, proteins induce the misfolding of other proteins they touch down a specific neuronal pathway. Prion diseases (such as mad cow disease) that involve transmission of misfolded proteins are thought to be infectious between people. "There is no evidence that Alzheimer's or other dementias are contagious in that way, which is why their transmission is called prion-like."
Simple Explanation for Clinically Observed Patterns of Dementia
Dr. Raj calls his model of trans-neuronal spread of misfolded proteins "very simple." It models the same process by which any gas diffuses in air, except that in the case of dementias the diffusion process occurs along connected neural fiber tracts in the brain.
"This is a common process by which any disease-causing protein can result in a variety of dementias," he says.
The model identifies the neural sub-networks in the brain into which misfolded proteins will collect before moving on to other brain areas that are connected by networks of neurons. In the process the proteins alter normal functioning of all brain areas they visit.
"What is new and really quite remarkable is the network diffusion model itself, which acts on the normal brain connectivity network and manages to reproduce many known aspects of whole brain disease patterns in dementias," Dr. Raj says. "This provides a very simple explanation for why different dementias appear to target specific areas of the brain."
In the study, he was able to match patterns from the diffusion model, which traced protein disbursal in a healthy brain, to the patterns of brain atrophy observed in patients with either Alzheimer's disease or FTD. This degeneration was measured using MRI and other tools that could quantify the amount of brain volume loss experienced in each region of the patient's brain. Co-author Amy Kuceyeski, Ph.D., a postdoctoral fellow who works with Dr. Raj, helped analyze brain volume measurements in the diseased brains.
"Our study demonstrates that such a spreading mechanism leads directly to the observed patterns of atrophy one sees in various dementias," Dr. Raj says. "While the classic patterns of dementia are well known, this is the first model to relate brain network properties to the patterns and explain them in a deterministic and predictive manner."
###
The study's third contributing author is Michael Weiner, M.D., professor of radiology at the University of California at San Francisco, and the principal investigator of the Alzheimer's Disease Neuroimaging Initiative, funded by the National Institutes of Health.
The study was funded by the National Institutes of Health. None of the authors have any competing financial interest to disclose.
Weill Cornell Medical College
Weill Cornell Medical College, Cornell University's medical school located in New York City, is committed to excellence in research, teaching, patient care and the advancement of the art and science of medicine, locally, nationally and globally. Physicians and scientists of Weill Cornell Medical College are engaged in cutting-edge research from bench to bedside, aimed at unlocking mysteries of the human body in health and sickness and toward developing new treatments and prevention strategies. In its commitment to global health and education, Weill Cornell has a strong presence in places such as Qatar, Tanzania, Haiti, Brazil, Austria and Turkey. Through the historic Weill Cornell Medical College in Qatar, the Medical College is the first in the U.S. to offer its M.D. degree overseas. Weill Cornell is the birthplace of many medical advances -- including the development of the Pap test for cervical cancer, the synthesis of penicillin, the first successful embryo-biopsy pregnancy and birth in the U.S., the first clinical trial of gene therapy for Parkinson's disease, and most recently, the world's first successful use of deep brain stimulation to treat a minimally conscious brain-injured patient. Weill Cornell Medical College is affiliated with NewYork-Presbyterian Hospital, where its faculty provides comprehensive patient care at NewYork-Presbyterian Hospital/Weill Cornell Medical Center. The Medical College is also affiliated with the Methodist Hospital in Houston. For more information, visit weill.cornell.edu.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Fresh soup brand New Covent Garden is celebrating the ?Best of?British? with its latest soup of the month.
NEW YORK, March 20, 2012 /PRNewswire-USNewswire/ -- Spring officially begins today and, while this winter's mild, dry conditions have reduced the likelihood of severe flooding events caused by melting snow in some parts of the country, it has not eliminated the risk of flooding caused by rain, hurricanes or other disasters, according to the Insurance Information Institute (I.I.I.). ![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 21-Mar-2012
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